Mitochondrial dysfunction manifests in the early stages of Alzheimer disease
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منابع مشابه
Deconstructing Mitochondrial Dysfunction in Alzheimer Disease
There is mounting evidence showing that mitochondrial damage plays an important role in Alzheimer disease. Increased oxygen species generation and deficient mitochondrial dynamic balance have been suggested to be the reason as well as the consequence of Alzheimer-related pathology. Mitochondrial damage has been related to amyloid-beta or tau pathology or to the presence of specific presenilin-1...
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alzheimer disease is one form of dementia in old age. alzheimer disease, the incurable disease, which is usually in the seventh decade of human life, shows its symptoms. the disease may be present for years without clinical symptoms. the current study identified the genes with altered expression in patients with alzheimer disease. the important sequence of each gene in alzheimer disease was fou...
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BACKGROUND Executive dysfunction (EDF) is common in Alzheimer disease (AD); however, its relationship to other symptoms is difficult to assess in patients with AD. OBJECTIVES To determine the prevalence of EDF and study its relationship to cognitive, functional, and neuropsychiatric symptoms in patients with AD. DESIGN, SETTING, AND PATIENTS A retrospective analysis of data from participant...
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IMPORTANCE Epileptic activity associated with Alzheimer disease (AD) deserves increased attention because it has a harmful impact on these patients, can easily go unrecognized and untreated, and may reflect pathogenic processes that also contribute to other aspects of the illness. We report key features of AD-related seizures and epileptiform activity that are instructive for clinical practice ...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2020
ISSN: 1759-4758,1759-4766
DOI: 10.1038/s41582-020-0353-3